Selective glucocorticoid receptor translational isoforms reveal glucocorticoid-induced apoptotic transcriptomes
نویسندگان
چکیده
منابع مشابه
Selective regulation of bone cell apoptosis by translational isoforms of the glucocorticoid receptor.
Glucocorticoids are widely used in the treatment of inflammatory and other diseases. However, high-dose or chronic administration often triggers troublesome side effects such as metabolic syndrome and osteoporosis. We recently described that one glucocorticoid receptor gene produces eight translational glucocorticoid receptor isoforms that have distinct gene-regulatory abilities. We show here t...
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Glucocorticoids (GC) are the most common used anti-inflammatory and immunosuppressive drugs in the treatment of rheumatic and other inflammatory diseases. Their therapeutic effects are considered to be mediated by four different mechanisms of action: the classical genomic mechanism of action caused by the cytosolic glucocorticoid receptor (cGCR); secondary non-genomic effects which are also ini...
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In 1950 Hench, Kendall, and Reichstein received the Nobel Prize in Medicine for the characterization and isolation of glucocorticoids and the subsequent discovery of their antiinflammatory properties. To date, glucocorticoids are still widelyprescribedandplayanimportantrole inthetreatment of a variety of clinical disorders, including inflammatory diseases, autoimmune disorders, and hematologica...
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Glucocorticoids are necessary for life after birth and regulate numerous homeostatic functions in man, including glucose homeostasis, protein catabolism, skeletal growth, respiratory function, inflammation, development, behavior, and apoptosis. In a clinical setting, they are widely used as anti-inflammatory agents to control both acute and chronic inflammation. Unfortunately, owing to their br...
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The mechanisms by which glucocorticoid receptor (GR) mediates glucocorticoid (GC)-induced apoptosis are unknown. We studied the role of mitochondrial GR in this process. Dexamethasone induces GR translocation to the mitochondria in GC-sensitive, but not in GC-resistant, T cell lines. In contrast, nuclear GR translocation occurs in all cell types. Thymic epithelial cells, which cause apoptosis o...
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ژورنال
عنوان ژورنال: Cell Death & Disease
سال: 2013
ISSN: 2041-4889
DOI: 10.1038/cddis.2012.193